Reaction Details | |||
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Target | Solute carrier family 12 member 5 | ||
Ligand | BDBM44170 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 | ||
EC50 | 11300±n/a nM | ||
Citation | ![]() | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Solute carrier family 12 member 5 | |||
Name: | Solute carrier family 12 member 5 | ||
Synonyms: | Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | S12A5_HUMAN | SLC12A5 | Solute carrier family 12 member 5 | electroneutral potassium-chloride cotransporter KCC2 | hKCC2 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 126185.18 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_828024 | ||
Residue: | 1139 | ||
Sequence: |
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BDBM44170 | |||
n/a | |||
Name | BDBM44170 | ||
Synonyms: | 2-[[(2S,3R,5R,6S,8R,9R)-2-[(1S)-2-keto-1-methyl-2-(1H-pyrrol-2-yl)ethyl]-3,5,9-trimethyl-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-5-(methylamino)-1,3-benzoxazole-4-carboxylic acid | 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxidanylidene-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid | 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid | Calcimycin A23187 | MLS001056783 | SMR000326983 | cid_11957499 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H37N3O6 | ||
Mol. Mass. | 523.6206 | ||
SMILES | CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@H]([C@H](C)C(=O)c3ccc[nH]3)[C@H](C)C[C@H]4C)nc2c1C(O)=O | ||
Structure | ![]() |