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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Heat shock protein HSP 90-alpha | ||
| Ligand | BDBM265059 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Malachite Green ATPase assay | ||
| IC50 | <10000±n/a nM | ||
| Citation |  Drysdale, MJ; Dymock, BW; Finch, H; Webb, P; McDonald, E; James, KE; Cheung, KM; Matthews, TP Isoxazole compounds as inhibitors of heat shock proteins US Patent US9718793 Publication Date 8/1/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Heat shock protein HSP 90-alpha | |||
| Name: | Heat shock protein HSP 90-alpha | ||
| Synonyms: | HS90A_HUMAN | HSP 86 | HSP86 | HSP90A | HSP90AA1 | HSPC1 | HSPCA | Heat Shock Protein 90 (Hsp90) | Heat shock 86 kDa | Heat shock protein HSP 90 (HSP90) | Heat shock protein HSP 90-alpha (HSP90) | Heat shock protein HSP 90-alpha (HSP90A) | LAP-2 | LPS-associated protein 2 | Lipopolysaccharide-associated protein 2 | Renal carcinoma antigen NY-REN-38 | heat shock protein 90kDa alpha (cytosolic), class A member 1 isoform 2 | ||
| Type: | Molecular Chaperone | ||
| Mol. Mass.: | 84623.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P07900 | ||
| Residue: | 732 | ||
| Sequence: |
| ||
| BDBM265059 | |||
| n/a | |||
| Name | BDBM265059 | ||
| Synonyms: | US10413550, Example 12c | US11234987, Example 12c | US9718793, 12c$#167; | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H14N2O3S | ||
| Mol. Mass. | 350.391 | ||
| SMILES | Cc1cc(O)cc(O)c1-c1oncc1-c1csc(n1)-c1ccccc1 |(-1.74,-5.37,;-1.74,-3.83,;-3.07,-3.06,;-3.07,-1.52,;-4.41,-.75,;-1.74,-.75,;-.41,-1.52,;.93,-.75,;-.41,-3.06,;.93,-3.83,;1.4,-5.29,;2.94,-5.29,;3.42,-3.83,;2.17,-2.92,;2.94,-1.59,;4.41,-1.11,;4.41,.43,;2.94,.9,;2.04,-.34,;2.54,2.39,;3.63,3.48,;3.23,4.97,;1.75,5.37,;.66,4.28,;1.06,2.79,)| | ||
| Structure | 
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