Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP |
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Ligand | BDBM44259 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SAR analysis of Antagonists of IAP-family anti-apoptotic proteins |
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IC50 | 5200±500 nM |
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Citation | PubChem, PC SAR analysis of Antagonists of IAP-family anti-apoptotic proteins PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase XIAP |
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Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
Type: | Protein |
Mol. Mass.: | 56685.27 |
Organism: | Homo sapiens (Human) |
Description: | P98170 |
Residue: | 497 |
Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM44259 |
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n/a |
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Name | BDBM44259 |
Synonyms: | (1R)-2-[2-cyclohexyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-1-oxoethyl]-N-(diphenylmethyl)-1-cyclopentanecarboxamide;2,2,2-trifluoroacetic acid | (1R)-2-[2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]ethanoyl]-N-(diphenylmethyl)cyclopentane-1-carboxamide;2,2,2-tris(fluoranyl)ethanoic acid | (1R)-N-benzhydryl-2-[2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]cyclopentane-1-carboxamide;2,2,2-trifluoroacetic acid | (1R)-N-benzhydryl-2-[2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]cyclopentanecarboxamide;2,2,2-trifluoroacetic acid | MLS-0390970.0001 | cid_25199555 |
Type | Small organic molecule |
Emp. Form. | C31H41N3O3 |
Mol. Mass. | 503.6755 |
SMILES | CN[C@@H](C)C(=O)NC(C1CCCCC1)C(=O)C1CCC[C@H]1C(=O)NC(c1ccccc1)c1ccccc1 |
Structure |
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