Reaction Details |
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Target | E3 ubiquitin-protein ligase XIAP |
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Ligand | BDBM44287 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SAR analysis of Antagonists of IAP-family anti-apoptotic proteins |
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IC50 | 3900±1000 nM |
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Citation | PubChem, PC SAR analysis of Antagonists of IAP-family anti-apoptotic proteins PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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E3 ubiquitin-protein ligase XIAP |
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Name: | E3 ubiquitin-protein ligase XIAP |
Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
Type: | Protein |
Mol. Mass.: | 56685.27 |
Organism: | Homo sapiens (Human) |
Description: | P98170 |
Residue: | 497 |
Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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BDBM44287 |
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n/a |
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Name | BDBM44287 |
Synonyms: | CHEMBL1625863 | MLS-0412059.0001 | cid_44176342 | formic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-N-[(2S)-3-methyl-1-(1-naphthalenylamino)-1-oxobutan-2-yl]butanamide | formic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(1S)-2-methyl-1-(1-naphthylcarbamoyl)propyl]butyramide | formic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-3-methyl-1-(naphthalen-1-ylamino)-1-oxobutan-2-yl]butanamide | methanoic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-3-methyl-1-(naphthalen-1-ylamino)-1-oxidanylidene-butan-2-yl]butanamide |
Type | Small organic molecule |
Emp. Form. | C24H34N4O3 |
Mol. Mass. | 426.5518 |
SMILES | CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)Nc1cccc2ccccc12 |
Structure |
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