| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
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| Ligand | BDBM44299 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SAR analysis of Antagonists of IAP-family anti-apoptotic proteins |
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| IC50 | 4000±800 nM |
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| Citation |  PubChem, PC SAR analysis of Antagonists of IAP-family anti-apoptotic proteins PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| E3 ubiquitin-protein ligase XIAP |
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| Name: | E3 ubiquitin-protein ligase XIAP |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56685.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170 |
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| Residue: | 497 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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| BDBM44299 |
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| n/a |
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| Name | BDBM44299 |
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| Synonyms: | MLS-0391062.0001 | [[amino-[(4S)-4-[[(2S)-3-methyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-1-oxobutyl]amino]-5-oxo-5-(1,2,3,4-tetrahydronaphthalen-1-ylamino)pentyl]iminomethyl]amino]-hydroxy-oxoammonium;formic acid | cid_44182169 | formic acid;hydroxy-[[N'-[(4S)-4-[[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]amino]-5-oxo-5-(1,2,3,4-tetrahydronaphthalen-1-ylamino)pentyl]carbamimidoyl]amino]-oxoazanium | formic acid;hydroxy-keto-[[N'-[(4S)-5-keto-4-[[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]amino]-5-(tetralin-1-ylamino)pentyl]amidino]amino]ammonium | methanoic acid;[[N'-[(4S)-4-[[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]amino]-5-oxidanylidene-5-(1,2,3,4-tetrahydronaphthalen-1-ylamino)pentyl]carbamimidoyl]amino]-oxidanyl-oxidanylidene-azanium |
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| Type | Small organic molecule |
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| Emp. Form. | C25H41N8O5 |
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| Mol. Mass. | 533.6431 |
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| SMILES | CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N[N+](O)=O)C(=O)NC1CCCc2ccccc12 |w:18.17| |
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| Structure | 
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