Ki Summary

Reaction Details

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Target

Ephrin type-A receptor 4

Ligand

BDBM44497

Substrate/Competitor

n/a

Meas. Tech.

Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists

IC50

4620±n/a nM

Citation

PubChem, PC Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Ephrin type-A receptor 4

Name:

Ephrin type-A receptor 4

Synonyms:

EPHA4_MOUSE | Eph receptor A4 | Epha4 | Sek | Sek1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

109812.17

Organism:

Mus musculus

Description:

gi_34328113

Residue:

986

Sequence:

MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVS
KYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHMSQDDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV

BDBM44497

n/a

Name

BDBM44497

Synonyms:

6-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-3,4-diphenyl-thieno[2,3-c]pyridazin-5-amine | 6-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-3,4-diphenylthieno[2,3-c]pyridazin-5-amine | 6-[5-(ethylsulfanyl)-1,3,4-oxadiazol-2-yl]-3,4-diphenylthieno[2,3-c]pyridazin-5-amine | 6-[5-(ethylthio)-1,3,4-oxadiazol-2-yl]-3,4-diphenyl-5-thieno[2,3-c]pyridazinamine | MLS000545814 | SMR000161018 | [6-[5-(ethylthio)-1,3,4-oxadiazol-2-yl]-3,4-diphenyl-thieno[2,3-c]pyridazin-5-yl]amine | cid_6406850

Type

Small organic molecule

Emp. Form.

C22H17N5OS2

Mol. Mass.

431.533

SMILES

CCSc1nnc(o1)-c1sc2nnc(-c3ccccc3)c(-c3ccccc3)c2c1N

Structure