| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Solute carrier family 12 member 5 |
|---|
| Ligand | BDBM47512 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 |
|---|
| EC50 | 8120±n/a nM |
|---|
| Citation |  PubChem, PC Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 PubChem Bioassay(2009)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Solute carrier family 12 member 5 |
|---|
| Name: | Solute carrier family 12 member 5 |
|---|
| Synonyms: | Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | S12A5_HUMAN | SLC12A5 | Solute carrier family 12 member 5 | electroneutral potassium-chloride cotransporter KCC2 | hKCC2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 126185.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_828024 |
|---|
| Residue: | 1139 |
|---|
| Sequence: | MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG
KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
|
|
|
|---|
| BDBM47512 |
|---|
| n/a |
|---|
| Name | BDBM47512 |
|---|
| Synonyms: | 1-(4-methylphenyl)-2-[[5-(8-quinolinyloxymethyl)-1,3,4-oxadiazol-2-yl]thio]ethanone | 1-(4-methylphenyl)-2-[[5-(quinolin-8-yloxymethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone | 1-(p-tolyl)-2-[[5-(8-quinolyloxymethyl)-1,3,4-oxadiazol-2-yl]thio]ethanone | 2-[5-(Quinolin-8-yloxymethyl)-[1,3,4]oxadiazol-2-ylsulfanyl]-1-p-tolyl-ethanone | MLS000071760 | SMR000003497 | cid_650551 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H17N3O3S |
|---|
| Mol. Mass. | 391.443 |
|---|
| SMILES | Cc1ccc(cc1)C(=O)CSc1nnc(COc2cccc3cccnc23)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
