| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 12 member 5 |
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| Ligand | BDBM44180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 |
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| EC50 | 10800±n/a nM |
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| Citation |  PubChem, PC Identification of Novel Modulators of Cl- dependent Transport Process via HTS; Dose-dependent Assay with KCC2 PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Solute carrier family 12 member 5 |
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| Name: | Solute carrier family 12 member 5 |
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| Synonyms: | Electroneutral potassium-chloride cotransporter 2 | K-Cl cotransporter 2 | KCC2 | KIAA1176 | Neuronal K-Cl cotransporter | S12A5_HUMAN | SLC12A5 | Solute carrier family 12 member 5 | electroneutral potassium-chloride cotransporter KCC2 | hKCC2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126185.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_828024 |
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| Residue: | 1139 |
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| Sequence: | MSRRFTVTSLPPAGPARSPDPESRRHSVADPRHLPGEDVKGDGNPKESSPFINSTDTEKG
KEYDGKNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRFLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERSGMTSVGLADGTPIDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLENHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETAGDSEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVKKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEHLDRVMLVRGGGREVITIYS
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| BDBM44180 |
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| n/a |
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| Name | BDBM44180 |
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| Synonyms: | 1-[2-(4-Benzyl-piperidin-1-yl)-2-oxo-ethyl]-4-methyl-1,4-dihydro-pyrrolo[3,2-b]pyrrole-2-carboxylic acid ethyl ester | 1-methyl-4-[2-oxo-2-[4-(phenylmethyl)-1-piperidinyl]ethyl]-5-pyrrolo[3,2-b]pyrrolecarboxylic acid ethyl ester | 4-[2-(4-benzylpiperidino)-2-keto-ethyl]-1-methyl-pyrrolo[3,2-b]pyrrole-5-carboxylic acid ethyl ester | MLS000068235 | SMR000008292 | cid_651846 | ethyl 1-methyl-4-[2-oxidanylidene-2-[4-(phenylmethyl)piperidin-1-yl]ethyl]pyrrolo[3,2-b]pyrrole-5-carboxylate | ethyl 4-[2-(4-benzylpiperidin-1-yl)-2-oxoethyl]-1-methylpyrrolo[3,2-b]pyrrole-5-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C24H29N3O3 |
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| Mol. Mass. | 407.5054 |
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| SMILES | CCOC(=O)c1cc2n(C)ccc2n1CC(=O)N1CCC(Cc2ccccc2)CC1 |
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| Structure | 
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