Ki Summary

Reaction Details

Report a problem with these data

Target

Regulator of G-protein signaling 8

Ligand

BDBM47716

Substrate/Competitor

n/a

Meas. Tech.

Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.

EC50

>30000±n/a nM

Citation

PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 8

Name:

Regulator of G-protein signaling 8

Synonyms:

RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

20925.80

Organism:

Homo sapiens (Human)

Description:

gi_74355113

Residue:

180

Sequence:

MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVL
LSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPRE
VNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS

BDBM47716

n/a

Name

BDBM47716

Synonyms:

1-(4-fluorophenyl)-5-methyl-4,6-dioxo-3-(phenylmethyl)-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylic acid methyl ester | 1-Benzyl-3-(4-fluoro-phenyl)-5-methyl-4,6-dioxo-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester | 3-benzyl-1-(4-fluorophenyl)-4,6-diketo-5-methyl-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylic acid methyl ester | MLS000122793 | SMR000120143 | cid_3217311 | methyl 1-(4-fluorophenyl)-5-methyl-4,6-bis(oxidanylidene)-3-(phenylmethyl)-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylate | methyl 3-benzyl-1-(4-fluorophenyl)-5-methyl-4,6-dioxo-1,2,3a,6a-tetrahydropyrrolo[3,4-c]pyrrole-3-carboxylate

Type

Small organic molecule

Emp. Form.

C22H21FN2O4

Mol. Mass.

396.4115

SMILES

COC(=O)C1(Cc2ccccc2)NC(C2C1C(=O)N(C)C2=O)c1ccc(F)cc1

Structure