Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M4

Ligand

BDBM48053

Substrate/Competitor

n/a

Meas. Tech.

Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency

EC50

0.00506±n/a nM

Citation

PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Muscarinic acetylcholine receptor M4

Name:

Muscarinic acetylcholine receptor M4

Synonyms:

ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4

Type:

Enzyme Catalytic Domain

Mol. Mass.:

52841.70

Organism:

RAT

Description:

Cholinergic, muscarinic M4 CHRM4 RAT::P08485

Residue:

477

Sequence:

MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

BDBM48053

n/a

Name

BDBM48053

Synonyms:

3-amino-4,6-dimethyl-N-[4-(trifluoromethoxy)benzyl]thieno[2,3-b]pyridine-2-carboxamide | 3-amino-4,6-dimethyl-N-[[4-(trifluoromethoxy)phenyl]methyl]-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-4,6-dimethyl-N-[[4-(trifluoromethoxy)phenyl]methyl]thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-4,6-dimethyl-N-[[4-(trifluoromethyloxy)phenyl]methyl]thieno[2,3-b]pyridine-2-carboxamide | VU0402480-1 | cid_44176131

Type

Small organic molecule

Emp. Form.

C18H16F3N3O2S

Mol. Mass.

395.399

SMILES

Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc(OC(F)(F)F)cc1

Structure