| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
|---|
| Ligand | BDBM48068 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency |
|---|
| EC50 | 2580±n/a nM |
|---|
| Citation |  PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Muscarinic acetylcholine receptor M4 |
|---|
| Name: | Muscarinic acetylcholine receptor M4 |
|---|
| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 52841.70 |
|---|
| Organism: | RAT |
|---|
| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
|
|
|
|---|
| BDBM48068 |
|---|
| n/a |
|---|
| Name | BDBM48068 |
|---|
| Synonyms: | 3-amino-6-[3-(dimethylamino)propoxy]-4-methyl-N-(3-oxetanyl)-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-6-[3-(dimethylamino)propoxy]-4-methyl-N-(oxetan-3-yl)thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-6-[3-(dimethylamino)propoxy]-4-methyl-N-(oxetan-3-yl)thieno[2,3-b]pyridine-2-carboxamide | VU0359439 | cid_45142477 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H24N4O3S |
|---|
| Mol. Mass. | 364.462 |
|---|
| SMILES | CN(C)CCCOc1cc(C)c2c(N)c(sc2n1)C(=O)NC1COC1 |
|---|
| Structure | 
|
|---|
Search and Browse
