| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM48069 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency |
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| EC50 | 2750±n/a nM |
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| Citation |  PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 52841.70 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M4 CHRM4 RAT::P08485 |
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| Residue: | 477 |
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| Sequence: | MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM48069 |
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| n/a |
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| Name | BDBM48069 |
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| Synonyms: | 3-amino-N-(2,5-difluorobenzyl)-6-[3-(dimethylamino)propoxy]-4-methyl-thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-[(2,5-difluorophenyl)methyl]-6-[3-(dimethylamino)propoxy]-4-methyl-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-[(2,5-difluorophenyl)methyl]-6-[3-(dimethylamino)propoxy]-4-methylthieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-N-[[2,5-bis(fluoranyl)phenyl]methyl]-6-[3-(dimethylamino)propoxy]-4-methyl-thieno[2,3-b]pyridine-2-carboxamide | VU0359451 | cid_45142478 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24F2N4O2S |
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| Mol. Mass. | 434.503 |
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| SMILES | CN(C)CCCOc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1cc(F)ccc1F |
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| Structure | 
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