Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M4

Ligand

BDBM48076

Substrate/Competitor

n/a

Meas. Tech.

Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency

EC50

1610±n/a nM

Citation

PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Muscarinic acetylcholine receptor M4

Name:

Muscarinic acetylcholine receptor M4

Synonyms:

ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4

Type:

Enzyme Catalytic Domain

Mol. Mass.:

52841.70

Organism:

RAT

Description:

Cholinergic, muscarinic M4 CHRM4 RAT::P08485

Residue:

477

Sequence:

MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQ
LQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMN
LLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPD
NQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTL
AFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSAT
QNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPA
TPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLV
NTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR

BDBM48076

n/a

Name

BDBM48076

Synonyms:

3-amino-N-(2,3-difluorobenzyl)-4-methyl-6-(4-pyridylmethoxy)thieno[2,3-b]pyridine-2-carboxamide | 3-amino-N-[(2,3-difluorophenyl)methyl]-4-methyl-6-(pyridin-4-ylmethoxy)-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-N-[(2,3-difluorophenyl)methyl]-4-methyl-6-(pyridin-4-ylmethoxy)thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-N-[[2,3-bis(fluoranyl)phenyl]methyl]-4-methyl-6-(pyridin-4-ylmethoxy)thieno[2,3-b]pyridine-2-carboxamide | ML173 | VU0359508 | cid_45142486

Type

Small organic molecule

Emp. Form.

C22H18F2N4O2S

Mol. Mass.

440.466

SMILES

Cc1cc(OCc2ccncc2)nc2sc(C(=O)NCc3cccc(F)c3F)c(N)c12

Structure