Ki Summary

Reaction Details

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Target

Alkaline phosphatase, tissue-nonspecific isozyme

Ligand

BDBM43790

Substrate/Competitor

n/a

Meas. Tech.

SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay

EC50

3890±n/a nM

Citation

PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Alkaline phosphatase, tissue-nonspecific isozyme

Name:

Alkaline phosphatase, tissue-nonspecific isozyme

Synonyms:

ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor

Type:

PROTEIN

Mol. Mass.:

57306.17

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1448917

Residue:

524

Sequence:

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

BDBM43790

n/a

Name

BDBM43790

Synonyms:

4-keto-N-(2-methoxyethyl)-4-[N'-(2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)hydrazino]butyramide | MLS-0240649.0001 | N-(2-methoxyethyl)-4-[(2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)hydrazo]-4-oxobutanamide | N-(2-methoxyethyl)-4-[2-(2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)hydrazinyl]-4-oxidanylidene-butanamide | N-(2-methoxyethyl)-4-[2-(2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)hydrazinyl]-4-oxobutanamide | cid_16009014

Type

Small organic molecule

Emp. Form.

C17H21N7O3

Mol. Mass.

371.3937

SMILES

COCCNC(=O)CCC(=O)NNc1nc2ccccc2c2nc(C)nn12

Structure