Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM51949 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. |
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IC50 | 59640±n/a nM |
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Citation | PubChem, PC Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 27125.88 |
Organism: | Pseudomonas aeruginosa |
Description: | gi_27368096 |
Residue: | 246 |
Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
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BDBM51949 |
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n/a |
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Name | BDBM51949 |
Synonyms: | (4Z)-4-[hydroxy(phenyl)methylene]-5-(2-pyridyl)-1-(3-pyridylmethyl)pyrrolidine-2,3-quinone | (4Z)-4-[hydroxy(phenyl)methylidene]-5-(2-pyridinyl)-1-(3-pyridinylmethyl)pyrrolidine-2,3-dione | (4Z)-4-[hydroxy(phenyl)methylidene]-5-pyridin-2-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione | (4Z)-4-[oxidanyl(phenyl)methylidene]-5-pyridin-2-yl-1-(pyridin-3-ylmethyl)pyrrolidine-2,3-dione | MLS000081490 | SMR000042569 | cid_5389446 |
Type | Small organic molecule |
Emp. Form. | C22H17N3O3 |
Mol. Mass. | 371.3887 |
SMILES | O=C(C1C(N(Cc2cccnc2)C(=O)C1=O)c1ccccn1)c1ccccc1 |
Structure |
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