Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM51958 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. |
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IC50 | 59640±n/a nM |
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Citation | PubChem, PC Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 27125.88 |
Organism: | Pseudomonas aeruginosa |
Description: | gi_27368096 |
Residue: | 246 |
Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
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BDBM51958 |
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n/a |
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Name | BDBM51958 |
Synonyms: | 2,2-Dimethyl-N-(5-{[(thiophen-2-ylmethyl)-carbamoyl]-methylsulfanyl}-[1,3,4]thiadiazol-2-yl)-propionamide | 2,2-dimethyl-N-[5-[2-oxidanylidene-2-(thiophen-2-ylmethylamino)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide | 2,2-dimethyl-N-[5-[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]sulfanyl-1,3,4-thiadiazol-2-yl]propanamide | 2,2-dimethyl-N-[5-[[2-oxo-2-(thiophen-2-ylmethylamino)ethyl]thio]-1,3,4-thiadiazol-2-yl]propanamide | MLS000529634 | N-[5-[[2-keto-2-(2-thenylamino)ethyl]thio]-1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide | SMR000122109 | cid_3220530 |
Type | Small organic molecule |
Emp. Form. | C14H18N4O2S3 |
Mol. Mass. | 370.513 |
SMILES | CC(C)(C)C(=O)Nc1nnc(SCC(=O)NCc2cccs2)s1 |
Structure |
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