Ki Summary

Reaction Details

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Target

Beta-lactamase

Ligand

BDBM51946

Substrate/Competitor

n/a

Meas. Tech.

FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.

IC50

59640±n/a nM

Citation

PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Beta-lactamase | metallo-beta-lactamase IMP-1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

27125.88

Organism:

Pseudomonas aeruginosa

Description:

gi_27368096

Residue:

246

Sequence:

MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN

BDBM51946

n/a

Name

BDBM51946

Synonyms:

3-(2-furanyl)-4-(1-naphthalenyl)-1H-1,2,4-triazole-5-thione | 3-(2-furyl)-4-(1-naphthyl)-1H-1,2,4-triazole-5-thione | 3-(furan-2-yl)-4-naphthalen-1-yl-1H-1,2,4-triazole-5-thione | MLS000038513 | SMR000059244 | cid_660813

Type

Small organic molecule

Emp. Form.

C16H11N3OS

Mol. Mass.

293.343

SMILES

S=c1[nH]nc(-c2ccco2)n1-c1cccc2ccccc12 |(10.99,-1.19,;9.53,-1.67,;9.05,-3.14,;7.51,-3.14,;7.04,-1.67,;5.57,-1.19,;5.1,.27,;3.56,.27,;3.08,-1.19,;4.33,-2.1,;8.28,-.77,;8.28,.77,;6.95,1.54,;6.95,3.08,;8.28,3.85,;9.62,3.08,;10.99,3.91,;12.39,3.12,;12.39,1.51,;10.99,.72,;9.62,1.54,)|

Structure