| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM51947 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. |
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| IC50 | 59640±n/a nM |
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| Citation |  PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 27125.88 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | gi_27368096 |
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| Residue: | 246 |
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| Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
|
|
|
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| BDBM51947 |
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| n/a |
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| Name | BDBM51947 |
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| Synonyms: | (4E)-5-(2,5-dimethoxyphenyl)-1-(2-furanylmethyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]pyrrolidine-2,3-dione | (4E)-5-(2,5-dimethoxyphenyl)-1-(2-furfuryl)-4-[hydroxy-(4-methoxyphenyl)methylene]pyrrolidine-2,3-quinone | (4E)-5-(2,5-dimethoxyphenyl)-1-(furan-2-ylmethyl)-4-[(4-methoxyphenyl)-oxidanyl-methylidene]pyrrolidine-2,3-dione | (4E)-5-(2,5-dimethoxyphenyl)-1-(furan-2-ylmethyl)-4-[hydroxy-(4-methoxyphenyl)methylidene]pyrrolidine-2,3-dione | MLS000077485 | SMR000057965 | cid_5389282 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23NO7 |
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| Mol. Mass. | 449.4526 |
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| SMILES | COc1ccc(cc1)C(=O)C1C(N(Cc2ccco2)C(=O)C1=O)c1cc(OC)ccc1OC |
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| Structure | 
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