| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
|---|
| Ligand | BDBM51953 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. |
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| IC50 | 59640±n/a nM |
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| Citation |  PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 27125.88 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | gi_27368096 |
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| Residue: | 246 |
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| Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
|
|
|
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| BDBM51953 |
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| n/a |
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| Name | BDBM51953 |
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| Synonyms: | 4-(4-methoxyphenyl)-2-(4-methyl-1-piperazinyl)-6-(trifluoromethyl)pyrimidine | 4-(4-methoxyphenyl)-2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine | 4-(4-methoxyphenyl)-2-(4-methylpiperazino)-6-(trifluoromethyl)pyrimidine | MLS000044538 | SMR000022315 | cid_2985091 |
|---|
| Type | Small organic molecule |
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| Emp. Form. | C17H19F3N4O |
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| Mol. Mass. | 352.3542 |
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| SMILES | COc1ccc(cc1)-c1cc(nc(n1)N1CCN(C)CC1)C(F)(F)F |
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| Structure | 
|
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