Ki Summary

Reaction Details

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Target

Beta-lactamase

Ligand

BDBM51974

Substrate/Competitor

n/a

Meas. Tech.

FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase.

IC50

59640±n/a nM

Citation

PubChem, PC FRET-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Beta-lactamase

Name:

Beta-lactamase

Synonyms:

Beta-lactamase | metallo-beta-lactamase IMP-1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

27125.88

Organism:

Pseudomonas aeruginosa

Description:

gi_27368096

Residue:

246

Sequence:

MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN

BDBM51974

n/a

Name

BDBM51974

Synonyms:

3-methyl-7-[(1-methyl-4-nitro-pyrazol-3-yl)carbonylamino]-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 3-methyl-7-[(1-methyl-4-nitropyrazole-3-carbonyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 3-methyl-7-[[(1-methyl-4-nitro-3-pyrazolyl)-oxomethyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 7-[({4-nitro-1-methyl-1H-pyrazol-3-yl}carbonyl)amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 8-keto-3-methyl-7-[(1-methyl-4-nitro-pyrazole-3-carbonyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | MLS000705418 | SMR000231345 | cid_4766021

Type

Small organic molecule

Emp. Form.

C13H13N5O6S

Mol. Mass.

367.337

SMILES

CC1=C(N2C(SC1)C(NC(=O)c1nn(C)cc1[N+]([O-])=O)C2=O)C(O)=O |t:1|

Structure