| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [1-37] |
|---|
| Ligand | BDBM54686 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant |
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| EC50 | 35±n/a nM |
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| Comments | Extracted from aid = 2043 and tid = 2 |
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| Citation |  PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| GTPase KRas [1-37] |
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| Name: | GTPase KRas [1-37] |
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| Synonyms: | ras protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 4034.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_190938 |
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| Residue: | 37 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
|
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|
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| BDBM54686 |
|---|
| n/a |
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| Name | BDBM54686 |
|---|
| Synonyms: | 2-amino-5-benzoyl-4-(3-bromo-4-methoxy-phenyl)-1-mesyl-pyrrole-3-carbonitrile | 2-amino-5-benzoyl-4-(3-bromo-4-methoxyphenyl)-1-methylsulfonyl-3-pyrrolecarbonitrile | 2-amino-5-benzoyl-4-(3-bromo-4-methoxyphenyl)-1-methylsulfonylpyrrole-3-carbonitrile | 2-azanyl-4-(3-bromanyl-4-methoxy-phenyl)-1-methylsulfonyl-5-(phenylcarbonyl)pyrrole-3-carbonitrile | UNM-0000305776 | cid_25220927 |
|---|
| Type | Small organic molecule |
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| Emp. Form. | C20H16BrN3O4S |
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| Mol. Mass. | 474.328 |
|---|
| SMILES | COc1ccc(cc1Br)-c1c(C#N)c(N)n(c1C(=O)c1ccccc1)S(C)(=O)=O |
|---|
| Structure | 
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|---|
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