Ki Summary

Reaction Details

Report a problem with these data

Target

Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)

Ligand

BDBM33183

Substrate/Competitor

n/a

Meas. Tech.

Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL

EC50

26380±n/a nM

Citation

PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)

Name:

Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)

Synonyms:

Type:

Homodimers/heterodimers with BAX, BAK and BCL2

Mol. Mass.:

26053.63

Organism:

Homo sapiens (Human)

Description:

gi_510901

Residue:

233

Sequence:

MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK

BDBM33183

n/a

Name

BDBM33183

Synonyms:

5-[[5-(5-chloranyl-2-nitro-phenyl)furan-2-yl]methylidene]-1,3-diazinane-2,4,6-trione | 5-[[5-(5-chloro-2-nitro-phenyl)-2-furyl]methylene]barbituric acid | 5-[[5-(5-chloro-2-nitrophenyl)-2-furanyl]methylidene]-1,3-diazinane-2,4,6-trione | 5-[[5-(5-chloro-2-nitrophenyl)furan-2-yl]methylidene]-1,3-diazinane-2,4,6-trione | MLS000689180 | SMR000283261 | cid_3122089

Type

Small organic molecule

Emp. Form.

C15H8ClN3O6

Mol. Mass.

361.694

SMILES

[O-]c1[nH]c(=O)[nH]c(=O)c1[CH+]c1ccc(o1)-c1cc(Cl)ccc1[N+]([O-])=O

Structure