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TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
LigandBDBM32266
Substrate/Competitorn/a
Meas. Tech.Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL
EC50 18360±n/a nM
Citation PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Name:Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:26053.63
Organism:Homo sapiens (Human)
Description:gi_510901
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM32266
n/a
NameBDBM32266
Synonyms:2,3-bis(2-furyl)-N-homoveratryl-quinoxaline-6-carboxamide | MLS000094619 | N-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-bis(2-furanyl)-6-quinoxalinecarboxamide | N-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-bis(furan-2-yl)quinoxaline-6-carboxamide | N-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-di-2-furylquinoxaline-6-carboxamide | SMR000030172 | cid_3238500
TypeSmall organic molecule
Emp. Form.C27H23N3O5
Mol. Mass.469.4886
SMILESCOc1ccc(CCNC(=O)c2ccc3nc(-c4ccco4)c(nc3c2)-c2ccco2)cc1OC
Structure
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