Reaction Details |
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Target | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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Ligand | BDBM32266 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL |
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EC50 | 18360±n/a nM |
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Citation | PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
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Name: | Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) |
Synonyms: | B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L) |
Type: | Homodimers/heterodimers with BAX, BAK and BCL2 |
Mol. Mass.: | 26053.63 |
Organism: | Homo sapiens (Human) |
Description: | gi_510901 |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM32266 |
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n/a |
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Name | BDBM32266 |
Synonyms: | 2,3-bis(2-furyl)-N-homoveratryl-quinoxaline-6-carboxamide | MLS000094619 | N-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-bis(2-furanyl)-6-quinoxalinecarboxamide | N-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-bis(furan-2-yl)quinoxaline-6-carboxamide | N-[2-(3,4-dimethoxyphenyl)ethyl]-2,3-di-2-furylquinoxaline-6-carboxamide | SMR000030172 | cid_3238500 |
Type | Small organic molecule |
Emp. Form. | C27H23N3O5 |
Mol. Mass. | 469.4886 |
SMILES | COc1ccc(CCNC(=O)c2ccc3nc(-c4ccco4)c(nc3c2)-c2ccco2)cc1OC |
Structure |
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