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TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
LigandBDBM54717
Substrate/Competitorn/a
Meas. Tech.Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL
EC50 45470±n/a nM
Citation PubChem, PC Confirmation dose response of hits from multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-XL PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Name:Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)
Synonyms:B-cell lymphoma-extra large protein (Bcl-xL) | B2CL1_HUMAN | BCL-xL | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-xL) | Isoform Bcl-X(L)
Type:Homodimers/heterodimers with BAX, BAK and BCL2
Mol. Mass.:26053.63
Organism:Homo sapiens (Human)
Description:gi_510901
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATAHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM54717
n/a
NameBDBM54717
Synonyms:4-bromanyl-2-[(E)-3-(2,3-dimethoxyphenyl)prop-2-enoyl]-7-(methylamino)cycloheptan-1-one | 4-bromo-2-[(E)-3-(2,3-dimethoxyphenyl)-1-oxoprop-2-enyl]-7-(methylamino)-1-cycloheptanone | 4-bromo-2-[(E)-3-(2,3-dimethoxyphenyl)acryloyl]-7-(methylamino)cycloheptanone | 4-bromo-2-[(E)-3-(2,3-dimethoxyphenyl)prop-2-enoyl]-7-(methylamino)cycloheptan-1-one | UNM-0000306221 | cid_44203220
TypeSmall organic molecule
Emp. Form.C19H24BrNO4
Mol. Mass.410.302
SMILESCNC1CCC(Br)CC(C(=O)C=Cc2cccc(OC)c2OC)C1=O |w:11.10|
Structure
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