Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | ||
| Ligand | BDBM59227 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Kinase Assay | ||
| IC50 | 839±n/a nM | ||
| Citation |  Caligiuri, M; Becker, F; Murthi, K; Kaplan, F; Dedier, S; Kaufmann, C; Machl, A; Zybarth, G; Richard, J; Bockovich, N; Kluge, A; Kley, N A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol12:1103-15 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | |||
| Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | ||
| Synonyms: | CDK4/CycD | CDK4/CycD1 | CDK4/Cyclin D1 | CDK4/D1 | Cyclin-Dependent Kinase 4 (CDK4) | Cyclin-dependent kinase 4 | Cyclin-dependent kinase 4/G1/S-specific cyclin D1 | Cyclin-dependent kinase 4/cyclin D1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | CDK4/D1 complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 4 | ||
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33731.96 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11802 | ||
| Residue: | 303 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G1/S-specific cyclin-D1 | ||
| Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33717.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 295 | ||
| Sequence: |
| ||
| BDBM59227 | |||
| n/a | |||
| Name | BDBM59227 | ||
| Synonyms: | Pyrazolopyrimidone analog, RGB-286147 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H22Cl2N4O3 | ||
| Mol. Mass. | 473.352 | ||
| SMILES | CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCO)cc3)[nH]c(=O)c12 |(-2.33,5.73,;-1.56,4.39,;-.02,4.39,;-2.33,3.06,;-1.43,1.81,;-2.33,.57,;-1.93,-.92,;-.44,-1.32,;.64,-.23,;-.05,-2.8,;-1.13,-3.89,;-2.62,-3.49,;-3.02,-2.01,;-4.51,-1.61,;-3.79,1.04,;-5.13,.27,;-6.46,1.04,;-7.8,.27,;-9.13,1.04,;-10.46,.27,;-11.8,1.04,;-11.8,2.58,;-13.13,3.35,;-14.46,2.58,;-15.8,3.35,;-17.13,2.58,;-10.46,3.35,;-9.13,2.58,;-6.46,2.58,;-5.13,3.35,;-5.13,4.89,;-3.79,2.58,)| | ||
| Structure | 
| ||