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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 | ||
| Ligand | BDBM59228 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | In Vitro Kinase Assay | ||
| IC50 | 7±n/a nM | ||
| Citation |  Caligiuri, M; Becker, F; Murthi, K; Kaplan, F; Dedier, S; Kaufmann, C; Machl, A; Zybarth, G; Richard, J; Bockovich, N; Kluge, A; Kley, N A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol12:1103-15 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 | |||
| Name: | Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 | ||
| Synonyms: | CDK2/CycE | CDK2/Cyclin E | CDK2/E | CDK2/E1 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-dependent kinase 2/G1/S-specific cyclin E1 | Cyclin-dependent kinase 2/cyclin E1 | ||
| Type: | Protein | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G1/S-specific cyclin-E1 | ||
| Synonyms: | CCNE | CCNE1 | CCNE1_HUMAN | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 47073.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 410 | ||
| Sequence: |
| ||
| BDBM59228 | |||
| n/a | |||
| Name | BDBM59228 | ||
| Synonyms: | Pyrazolopyrimidone analog, RGB-285940 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19Cl3N4O2 | ||
| Mol. Mass. | 477.771 | ||
| SMILES | COc1ccc(Cc2nc3n(nc(C(C)C)c3c(=O)[nH]2)-c2c(Cl)cc(Cl)cc2Cl)cc1 |(-14.46,2.58,;-13.13,3.35,;-11.8,2.58,;-11.8,1.04,;-10.46,.27,;-9.13,1.04,;-7.8,.27,;-6.46,1.04,;-5.13,.27,;-3.79,1.04,;-2.33,.57,;-1.43,1.81,;-2.33,3.06,;-1.56,4.39,;-2.33,5.73,;-.02,4.39,;-3.79,2.58,;-5.13,3.35,;-5.13,4.89,;-6.46,2.58,;-1.93,-.92,;-.44,-1.32,;.64,-.23,;-.05,-2.8,;-1.13,-3.89,;-.74,-5.38,;-2.62,-3.49,;-3.02,-2.01,;-4.51,-1.61,;-9.13,2.58,;-10.46,3.35,)| | ||
| Structure | 
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