Reaction Details | |||
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Target | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | ||
Ligand | BDBM59230 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Kinase Assay | ||
IC50 | 310±n/a nM | ||
Citation | Caligiuri, M; Becker, F; Murthi, K; Kaplan, F; Dedier, S; Kaufmann, C; Machl, A; Zybarth, G; Richard, J; Bockovich, N; Kluge, A; Kley, N A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol12:1103-15 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | |||
Name: | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | ||
Synonyms: | CDK1/B | CDK1/Cyclin B | CDK1/CyclinB | Cyclin B/Dependent Kinase 1 (CDK1) | Cyclin-Dependent Kinase 1 (CDK1) | Cyclin-dependent kinase 1/cyclin B1 | Cyclin-dependent kinase/G2/mitotic-specific cyclin 1 | cdk1 | ||
Type: | Protein Complex | ||
Mol. Mass.: | n/a | ||
Description: | CDK1/Cyclin B complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 1 | ||
Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 34101.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P06493 | ||
Residue: | 297 | ||
Sequence: |
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Component 2 | |||
Name: | G2/mitotic-specific cyclin-B1 | ||
Synonyms: | CCNB | CCNB1 | CCNB1_HUMAN | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 48340.95 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P14635 | ||
Residue: | 433 | ||
Sequence: |
| ||
BDBM59230 | |||
n/a | |||
Name | BDBM59230 | ||
Synonyms: | Pyrazolopyrimidone analog, RGB-285960 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H29Cl2N5O3 | ||
Mol. Mass. | 542.457 | ||
SMILES | CC(C)c1nn(-c2c(Cl)cccc2Cl)c2nc(Cc3ccc(OCCN4CCOCC4)cc3)[nH]c(=O)c12 |(-2.33,5.73,;-1.56,4.39,;-.02,4.39,;-2.33,3.06,;-1.43,1.81,;-2.33,.57,;-1.93,-.92,;-.44,-1.32,;.64,-.23,;-.05,-2.8,;-1.13,-3.89,;-2.62,-3.49,;-3.02,-2.01,;-4.51,-1.61,;-3.79,1.04,;-5.13,.27,;-6.46,1.04,;-7.8,.27,;-9.13,1.04,;-10.46,.27,;-11.8,1.04,;-11.8,2.58,;-13.13,3.35,;-14.46,2.58,;-15.8,3.35,;-17.13,2.58,;-18.47,3.35,;-19.8,2.58,;-19.8,1.04,;-18.47,.27,;-17.13,1.04,;-10.46,3.35,;-9.13,2.58,;-6.46,2.58,;-5.13,3.35,;-5.13,4.89,;-3.79,2.58,)| | ||
Structure |