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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | ||
| Ligand | BDBM59233 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Cell Proliferation Assay | ||
| IC50 | 5.5e+3±n/a nM | ||
| Citation |  Caligiuri, M; Becker, F; Murthi, K; Kaplan, F; Dedier, S; Kaufmann, C; Machl, A; Zybarth, G; Richard, J; Bockovich, N; Kluge, A; Kley, N A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression. Chem Biol12:1103-15 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | |||
| Name: | Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 | ||
| Synonyms: | CDK1/B | CDK1/Cyclin B | CDK1/CyclinB | Cyclin B/Dependent Kinase 1 (CDK1) | Cyclin-Dependent Kinase 1 (CDK1) | Cyclin-dependent kinase 1/cyclin B1 | Cyclin-dependent kinase/G2/mitotic-specific cyclin 1 | cdk1 | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | CDK1/Cyclin B complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 1 | ||
| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 34101.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P06493 | ||
| Residue: | 297 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | G2/mitotic-specific cyclin-B1 | ||
| Synonyms: | CCNB | CCNB1 | CCNB1_HUMAN | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48340.95 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P14635 | ||
| Residue: | 433 | ||
| Sequence: |
| ||
| BDBM59233 | |||
| n/a | |||
| Name | BDBM59233 | ||
| Synonyms: | Pyrazolopyrimidone analog, RGB-310590 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H13Cl3N4O2 | ||
| Mol. Mass. | 435.691 | ||
| SMILES | COc1ccc(Cc2nc3n(ncc3c(=O)[nH]2)-c2c(Cl)cc(Cl)cc2Cl)cc1 |(-14.46,2.58,;-13.13,3.35,;-11.8,2.58,;-11.8,1.04,;-10.46,.27,;-9.13,1.04,;-7.8,.27,;-6.46,1.04,;-5.13,.27,;-3.79,1.04,;-2.33,.57,;-1.43,1.81,;-2.33,3.06,;-3.79,2.58,;-5.13,3.35,;-5.13,4.89,;-6.46,2.58,;-1.93,-.92,;-.44,-1.32,;.33,.02,;-.05,-2.8,;-1.13,-3.89,;-.74,-5.38,;-2.62,-3.49,;-3.02,-2.01,;-4.51,-1.61,;-9.13,2.58,;-10.46,3.35,)| | ||
| Structure | 
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