| Reaction Details |
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 | Report a problem with these data |
| Target | Kappa-type opioid receptor |
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| Ligand | BDBM54823 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay |
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| IC50 | 5510±n/a nM |
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| Citation |  PubChem, PC uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Kappa-type opioid receptor |
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| Name: | Kappa-type opioid receptor |
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| Synonyms: | K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 42648.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41145 |
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| Residue: | 380 |
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| Sequence: | MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV
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| BDBM54823 |
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| n/a |
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| Name | BDBM54823 |
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| Synonyms: | 4,5-bis(chloranyl)-2-[2-(2,3-dihydroindol-1-yl)-2-oxidanylidene-ethyl]pyridazin-3-one | 4,5-dichloro-2-(2-indolin-1-yl-2-keto-ethyl)pyridazin-3-one | 4,5-dichloro-2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]-3-pyridazinone | 4,5-dichloro-2-[2-(2,3-dihydroindol-1-yl)-2-oxoethyl]pyridazin-3-one | MLS001003241 | SMR000344702 | cid_2430298 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11Cl2N3O2 |
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| Mol. Mass. | 324.162 |
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| SMILES | Clc1cnn(CC(=O)N2CCc3ccccc23)c(=O)c1Cl |
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| Structure | 
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