| Reaction Details |
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 | Report a problem with these data |
| Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Ligand | BDBM61863 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. |
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| IC50 | 6080±n/a nM |
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| Citation |  PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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| Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
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| Type: | Membrane; Single-pass membrane protein |
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| Mol. Mass.: | 37332.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07820 |
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| Residue: | 350 |
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| Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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| BDBM61863 |
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| n/a |
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| Name | BDBM61863 |
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| Synonyms: | 2-[(2,6-diketo-4,4-dimethyl-cyclohexyl)-(5-ethyl-4-nitro-2-thienyl)methyl]-5,5-dimethyl-cyclohexane-1,3-quinone | 2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(5-ethyl-4-nitro-2-thiophenyl)methyl]-5,5-dimethylcyclohexane-1,3-dione | 2-[(4,4-dimethyl-2,6-dioxocyclohexyl)-(5-ethyl-4-nitrothiophen-2-yl)methyl]-5,5-dimethylcyclohexane-1,3-dione | 2-[[4,4-dimethyl-2,6-bis(oxidanylidene)cyclohexyl]-(5-ethyl-4-nitro-thiophen-2-yl)methyl]-5,5-dimethyl-cyclohexane-1,3-dione | MLS000708681 | SMR000289248 | cid_1078769 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29NO6S |
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| Mol. Mass. | 447.544 |
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| SMILES | CCc1sc(cc1[N+]([O-])=O)C(C1C(=O)CC(C)(C)CC1=O)C1C(=O)CC(C)(C)CC1=O |
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| Structure | 
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