Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Ligand | BDBM61865 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. |
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IC50 | 9130±n/a nM |
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Citation | PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
Type: | Membrane; Single-pass membrane protein |
Mol. Mass.: | 37332.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07820 |
Residue: | 350 |
Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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BDBM61865 |
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n/a |
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Name | BDBM61865 |
Synonyms: | (6E)-4-(2-chlorobenzyl)-6-[(2-hydroxy-4-methyl-anilino)methylene]-2-nitro-cyclohexa-2,4-dien-1-one | (6E)-4-[(2-chlorophenyl)methyl]-6-[(2-hydroxy-4-methylanilino)methylidene]-2-nitro-1-cyclohexa-2,4-dienone | (6E)-4-[(2-chlorophenyl)methyl]-6-[(2-hydroxy-4-methylanilino)methylidene]-2-nitrocyclohexa-2,4-dien-1-one | (6E)-4-[(2-chlorophenyl)methyl]-6-[[(4-methyl-2-oxidanyl-phenyl)amino]methylidene]-2-nitro-cyclohexa-2,4-dien-1-one | 4-(2-chlorobenzyl)-2-{(E)-[(2-hydroxy-4-methylphenyl)imino]methyl}-6-nitrophenol | MLS000685576 | SMR000312540 | cid_5847352 |
Type | Small organic molecule |
Emp. Form. | C21H17ClN2O4 |
Mol. Mass. | 396.824 |
SMILES | Cc1ccc(\[NH+]=C\c2c[c-](Cc3ccccc3Cl)cc([N+]([O-])=O)c2=O)c(O)c1 |
Structure |
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