| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM60527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). |
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| IC50 | 12089±n/a nM |
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| Citation |  PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM60527 |
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| n/a |
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| Name | BDBM60527 |
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| Synonyms: | (5Z)-5-[[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylidene]-1-(3-chlorophenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[[5-(1H-benzimidazol-2-ylthio)-2-furanyl]methylidene]-1-(3-chlorophenyl)-1,3-diazinane-2,4,6-trione | (5Z)-5-[[5-(1H-benzimidazol-2-ylthio)-2-furyl]methylene]-1-(3-chlorophenyl)barbituric acid | 5-[1-[5-(1H-Benzoimidazol-2-ylsulfanyl)-furan-2-yl]-meth-(Z)-ylidene]-1-(3-chloro-phenyl)-pyrimidine-2,4,6-trione | MLS000587247 | SMR000211287 | cid_1895189 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H13ClN4O4S |
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| Mol. Mass. | 464.881 |
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| SMILES | Clc1cccc(c1)N1C(=O)NC(=O)C(=Cc2ccc(Sc3nc4ccccc4[nH]3)o2)C1=O |w:14.15| |
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| Structure | 
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