Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM52965 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). |
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IC50 | 27252±n/a nM |
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Citation | PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM52965 |
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n/a |
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Name | BDBM52965 |
Synonyms: | 1-O-methyl 4-O-(7-methyl-6,8-dioxo-3-thiophen-3-ylisochromen-7-yl) butanedioate | CMLD003572 | MLS000438829 | O1-methyl O4-[7-methyl-6,8-bis(oxidanylidene)-3-thiophen-3-yl-isochromen-7-yl] butanedioate | SMR000452585 | butanedioic acid O1-methyl ester O4-[7-methyl-6,8-dioxo-3-(3-thiophenyl)-2-benzopyran-7-yl] ester | cid_16759464 | succinic acid O4-[6,8-diketo-7-methyl-3-(3-thienyl)isochromen-7-yl] ester O1-methyl ester |
Type | Small organic molecule |
Emp. Form. | C19H16O7S |
Mol. Mass. | 388.391 |
SMILES | COC(=O)CCC(=O)OC1(C)C(=O)C=C2C=C(OC=C2C1=O)c1ccsc1 |c:15,18,t:13| |
Structure |
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