Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM55000 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). |
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IC50 | 25257±n/a nM |
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Citation | PubChem, PC Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM55000 |
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n/a |
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Name | BDBM55000 |
Synonyms: | (E)-N-[2-(2,6-difluoroanilino)-2-keto-ethyl]-N-ethyl-3-(2-quinolyl)acrylamide | (E)-N-[2-(2,6-difluoroanilino)-2-oxoethyl]-N-ethyl-3-(2-quinolinyl)-2-propenamide | (E)-N-[2-(2,6-difluoroanilino)-2-oxoethyl]-N-ethyl-3-quinolin-2-ylprop-2-enamide | (E)-N-[2-[[2,6-bis(fluoranyl)phenyl]amino]-2-oxidanylidene-ethyl]-N-ethyl-3-quinolin-2-yl-prop-2-enamide | MLS001128172 | SMR000713765 | cid_24979772 |
Type | Small organic molecule |
Emp. Form. | C22H19F2N3O2 |
Mol. Mass. | 395.402 |
SMILES | CCN(CC(=O)Nc1c(F)cccc1F)C(=O)\C=C\c1ccc2ccccc2n1 |
Structure |
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