Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM60311

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)

EC50

1568±1041 nM

Citation

PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM60311

n/a

Name

BDBM60311

Synonyms:

2-methyl-4,5-dioxo-3H-benzo[e]indole-1-carboxylic acid ethyl ester | 4,5-diketo-2-methyl-3H-benz[e]indole-1-carboxylic acid ethyl ester | MLS000701140 | SMR000226436 | cid_1736294 | ethyl 2-methyl-4,5-bis(oxidanylidene)-3H-benzo[e]indole-1-carboxylate | ethyl 2-methyl-4,5-dioxo-3H-benzo[e]indole-1-carboxylate | ethyl 2-methyl-4,5-dioxo-4,5-dihydro-3H-benzo[e]indole-1-carboxylate

Type

Small organic molecule

Emp. Form.

C16H13NO4

Mol. Mass.

283.2787

SMILES

CCOC(=O)c1c(C)[nH]c2c1-c1ccccc1C(=O)C2=O

Structure