Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM63402

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)

EC50

>195000±0 nM

Citation

PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM63402

n/a

Name

BDBM63402

Synonyms:

MLS000729334 | N-(1,3-benzodioxol-5-yl)-2-[1-(3-hydroxypropyl)tetrazol-5-yl]sulfanylacetamide | N-(1,3-benzodioxol-5-yl)-2-[[1-(3-hydroxypropyl)-5-tetrazolyl]thio]acetamide | N-(1,3-benzodioxol-5-yl)-2-[[1-(3-hydroxypropyl)tetrazol-5-yl]thio]acetamide | N-(1,3-benzodioxol-5-yl)-2-[[1-(3-oxidanylpropyl)-1,2,3,4-tetrazol-5-yl]sulfanyl]ethanamide | N-1,3-benzodioxol-5-yl-2-{[1-(3-hydroxypropyl)-1H-tetrazol-5-yl]thio}acetamide | SMR000307612 | cid_5295847

Type

Small organic molecule

Emp. Form.

C13H15N5O4S

Mol. Mass.

337.354

SMILES

OCCCn1nnnc1SCC(=O)Nc1ccc2OCOc2c1

Structure