Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM63403

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)

EC50

>195000±0 nM

Citation

PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM63403

n/a

Name

BDBM63403

Synonyms:

3-[(3,5-dichloro-2-pyridinyl)hydrazo]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[2-(3,5-dichloropyridin-2-yl)hydrazino]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[2-(3,5-dichloropyridin-2-yl)hydrazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[2-[3,5-bis(chloranyl)pyridin-2-yl]hydrazinyl]-1-(4-methoxyphenyl)pyrrolidine-2,5-dione | 3-[N'-(3,5-dichloro-2-pyridyl)hydrazino]-1-(4-methoxyphenyl)pyrrolidine-2,5-quinone | MLS000728774 | SMR000307052 | cid_4673902

Type

Small organic molecule

Emp. Form.

C16H14Cl2N4O3

Mol. Mass.

381.213

SMILES

COc1ccc(cc1)-n1c(O)cc(NNc2ncc(Cl)cc2Cl)c1O

Structure