Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM63411

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1)

EC50

>195000±0 nM

Citation

PubChem, PC Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM63411

n/a

Name

BDBM63411

Synonyms:

MLS000723409 | N-(2-{(2Z)-2-[1-(4-nitrophenyl)ethylidene]hydrazino}-2-oxoethyl)pyridine-2-carboxamide | N-[2-[2-[1-(4-nitrophenyl)ethylidene]hydrazinyl]-2-oxidanylidene-ethyl]pyridine-2-carboxamide | N-[2-[2-[1-(4-nitrophenyl)ethylidene]hydrazinyl]-2-oxoethyl]-2-pyridinecarboxamide | N-[2-[2-[1-(4-nitrophenyl)ethylidene]hydrazinyl]-2-oxoethyl]pyridine-2-carboxamide | N-[2-keto-2-[N'-[1-(4-nitrophenyl)ethylidene]hydrazino]ethyl]picolinamide | SMR000305004 | cid_16188123

Type

Small organic molecule

Emp. Form.

C16H15N5O4

Mol. Mass.

341.3214

SMILES

C[C+]([N-]NC(=O)CNC(=O)c1ccccn1)c1ccc(cc1)[N+]([O-])=O

Structure