Reaction Details |
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Target | Tumor necrosis factor |
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Ligand | BDBM65729 |
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Substrate/Competitor | n/a |
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Meas. Tech. | SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 |
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IC50 | >20000±n/a nM |
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Citation | PubChem, PC SAR analysis of inhibitors of TNFa specific NF-kB induction - Set 3 PubChem Bioassay(2010)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Tumor necrosis factor |
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Name: | Tumor necrosis factor |
Synonyms: | Cachectin | TNF | TNF-a | TNF-alpha | TNFA | TNFA_HUMAN | TNFSF2 | Tumor necrosis factor (TNF-alpha) | Tumor necrosis factor (TNFa) | Tumor necrosis factor alpha (TNFα) | Tumor necrosis factor ligand superfamily member 2 | Tumor necrosis factor, membrane form | Tumor necrosis factor, soluble form | tumor necrosis factor alpha |
Type: | Enzyme |
Mol. Mass.: | 25645.11 |
Organism: | Homo sapiens (Human) |
Description: | P01375 |
Residue: | 233 |
Sequence: | MSTESMIRDVELAEEALPKKTGGPQGSRRCLFLSLFSFLIVAGATTLFCLLHFGVIGPQR
EEFPRDLSLISPLAQAVRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELR
DNQLVVPSEGLYLIYSQVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRE
TPEGAEAKPWYEPIYLGGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL
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BDBM65729 |
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n/a |
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Name | BDBM65729 |
Synonyms: | 3-methyl-7-pentyl-8-(2-phenylethylsulfanyl)purine-2,6-dione | 3-methyl-7-pentyl-8-(2-phenylethylthio)purine-2,6-dione | 7-amyl-3-methyl-8-(phenethylthio)xanthine | MLS-0018316.0001 | cid_647508 |
Type | Small organic molecule |
Emp. Form. | C19H24N4O2S |
Mol. Mass. | 372.484 |
SMILES | CCCCCn1c(SCCc2ccccc2)nc2n(C)c(=O)[nH]c(=O)c12 |
Structure |
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