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TargetDNA damage-inducible transcript 3 protein
LigandBDBM61011
Substrate/Competitorn/a
Meas. Tech.Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50 4650±n/a nM
Citation PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
DNA damage-inducible transcript 3 protein
Name:DNA damage-inducible transcript 3 protein
Synonyms:Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:Enzyme Catalytic Domain
Mol. Mass.:19175.17
Organism:Mus musculus
Description:gi_160707929
Residue:168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
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  Blast E-value cutoff:
BDBM61011
n/a
NameBDBM61011
Synonyms:(3'S,4'R)-1'-(4-chlorophenyl)-2'-cyano-spiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylic acid dimethyl ester | (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyanospiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylic acid dimethyl ester | MLS000549148 | SMR000113936 | cid_9499902 | dimethyl (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyano-spiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylate | dimethyl (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyanospiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylate | dimethyl 1-(4-chlorophenyl)-2-cyanospiro[pyrazolidine-5,9'-(9'H)-fluorene]-3,4-dicarboxylate
TypeSmall organic molecule
Emp. Form.C26H20ClN3O4
Mol. Mass.473.908
SMILESCOC(=O)[C@@H]1[C@@H](C(=O)OC)C2(N(N1C#N)c1ccc(Cl)cc1)c1ccccc1-c1ccccc21
Structure
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