Ki Summary

Reaction Details

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Target

DNA damage-inducible transcript 3 protein

Ligand

BDBM61011

Substrate/Competitor

n/a

Meas. Tech.

Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress

IC50

4650±n/a nM

Citation

PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

DNA damage-inducible transcript 3 protein

Name:

DNA damage-inducible transcript 3 protein

Synonyms:

Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153

Type:

Enzyme Catalytic Domain

Mol. Mass.:

19175.17

Organism:

Mus musculus

Description:

gi_160707929

Residue:

168

Sequence:

MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA

BDBM61011

n/a

Name

BDBM61011

Synonyms:

(3'S,4'R)-1'-(4-chlorophenyl)-2'-cyano-spiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylic acid dimethyl ester | (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyanospiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylic acid dimethyl ester | MLS000549148 | SMR000113936 | cid_9499902 | dimethyl (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyano-spiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylate | dimethyl (3'S,4'R)-1'-(4-chlorophenyl)-2'-cyanospiro[fluorene-9,5'-pyrazolidine]-3',4'-dicarboxylate | dimethyl 1-(4-chlorophenyl)-2-cyanospiro[pyrazolidine-5,9'-(9'H)-fluorene]-3,4-dicarboxylate

Type

Small organic molecule

Emp. Form.

C26H20ClN3O4

Mol. Mass.

473.908

SMILES

COC(=O)[C@@H]1[C@@H](C(=O)OC)C2(N(N1C#N)c1ccc(Cl)cc1)c1ccccc1-c1ccccc21

Structure