| Reaction Details |
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 | Report a problem with these data |
| Target | DNA damage-inducible transcript 3 protein |
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| Ligand | BDBM66400 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress |
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| IC50 | <160±n/a nM |
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| Citation |  PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| DNA damage-inducible transcript 3 protein |
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| Name: | DNA damage-inducible transcript 3 protein |
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| Synonyms: | Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 19175.17 |
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| Organism: | Mus musculus |
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| Description: | gi_160707929 |
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| Residue: | 168 |
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| Sequence: | MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASL
AWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMK
EKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
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| BDBM66400 |
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| n/a |
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| Name | BDBM66400 |
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| Synonyms: | (E)-3-phenyl-N-[2,2,2-trichloro-1-[(4-methoxyphenyl)carbamothioylamino]ethyl]prop-2-enamide | (E)-3-phenyl-N-[2,2,2-trichloro-1-[(4-methoxyphenyl)thiocarbamoylamino]ethyl]acrylamide | (E)-3-phenyl-N-[2,2,2-trichloro-1-[[(4-methoxyanilino)-sulfanylidenemethyl]amino]ethyl]-2-propenamide | (E)-3-phenyl-N-[2,2,2-tris(chloranyl)-1-[(4-methoxyphenyl)carbamothioylamino]ethyl]prop-2-enamide | 3-phenyl-N-[2,2,2-trichloro-1-({[(4-methoxyphenyl)amino]carbonothioyl}amino)ethyl]acrylamide | MLS000573668 | SMR000184517 | cid_5717736 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18Cl3N3O2S |
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| Mol. Mass. | 458.789 |
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| SMILES | COc1ccc(NC(=S)NC(NC(=O)C=Cc2ccccc2)C(Cl)(Cl)Cl)cc1 |w:14.13| |
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| Structure | 
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