Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM72245

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

14640±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM72245

n/a

Name

BDBM72245

Synonyms:

(E)-N-[[4-(4-morpholinylmethyl)anilino]-sulfanylidenemethyl]-3-(3-nitrophenyl)-2-propenamide | (E)-N-[[4-(morpholin-4-ylmethyl)phenyl]carbamothioyl]-3-(3-nitrophenyl)prop-2-enamide | (E)-N-[[4-(morpholinomethyl)phenyl]thiocarbamoyl]-3-(3-nitrophenyl)acrylamide | 1-(4-Morpholin-4-ylmethyl-phenyl)-3-[(E)-3-(3-nitro-phenyl)-acryloyl]-thiourea | MLS000590207 | SMR000219418 | cid_1421763

Type

Small organic molecule

Emp. Form.

C21H22N4O4S

Mol. Mass.

426.489

SMILES

[O-][N+](=O)c1cccc(C=CC(=O)NC(=S)Nc2ccc(CN3CCOCC3)cc2)c1 |w:8.7|

Structure