Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM72250

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

82200±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM72250

n/a

Name

BDBM72250

Synonyms:

2-N-(3-chloro-4-methylphenyl)-4-N-methyl-5-nitropyrimidine-2,4,6-triamine | MLS000723368 | N2-(3-chloranyl-4-methyl-phenyl)-N4-methyl-5-nitro-pyrimidine-2,4,6-triamine | N2-(3-chloro-4-methylphenyl)-N4-methyl-5-nitropyrimidine-2,4,6-triamine | SMR000236504 | [6-amino-2-(3-chloro-4-methyl-anilino)-5-nitro-pyrimidin-4-yl]-methyl-amine | cid_4089250

Type

Small organic molecule

Emp. Form.

C12H13ClN6O2

Mol. Mass.

308.724

SMILES

CNc1nc(Nc2ccc(C)c(Cl)c2)nc(N)c1[N+]([O-])=O

Structure