Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM72266

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

6249±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM72266

n/a

Name

BDBM72266

Synonyms:

(3Z)-1-methyl-5-(morpholin-4-ylsulfonyl)-1H-indole-2,3-dione 3-[N-(4-methylphenyl)thiosemicarbazone] | 1-[(Z)-(1-methyl-5-morpholin-4-ylsulfonyl-2-oxidanylidene-indol-3-ylidene)amino]-3-(4-methylphenyl)thiourea | 1-[(Z)-(1-methyl-5-morpholin-4-ylsulfonyl-2-oxoindol-3-ylidene)amino]-3-(4-methylphenyl)thiourea | 1-[(Z)-(2-keto-1-methyl-5-morpholinosulfonyl-indolin-3-ylidene)amino]-3-(p-tolyl)thiourea | 1-[(Z)-[1-methyl-5-(4-morpholinylsulfonyl)-2-oxo-3-indolylidene]amino]-3-(4-methylphenyl)thiourea | MLS000586623 | SMR000208002 | cid_6018710

Type

Small organic molecule

Emp. Form.

C21H23N5O4S2

Mol. Mass.

473.568

SMILES

CN1C(=O)C(=NNC(=S)Nc2ccc(C)cc2)c2cc(ccc12)S(=O)(=O)N1CCOCC1 |w:5.5|

Structure