Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM43092

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

63700±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM43092

n/a

Name

BDBM43092

Synonyms:

4-chloranyl-N-[(3-methoxyphenyl)carbamothioyl]-2,5-dimethyl-pyrazole-3-carboxamide | 4-chloro-N-[(3-methoxyanilino)-sulfanylidenemethyl]-2,5-dimethyl-3-pyrazolecarboxamide | 4-chloro-N-[(3-methoxyphenyl)carbamothioyl]-2,5-dimethylpyrazole-3-carboxamide | 4-chloro-N-[(3-methoxyphenyl)thiocarbamoyl]-2,5-dimethyl-pyrazole-3-carboxamide | MLS000705983 | N-[(4-chloro-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]-N'-(3-methoxyphenyl)thiourea | SMR000227917 | cid_842089

Type

Small organic molecule

Emp. Form.

C14H15ClN4O2S

Mol. Mass.

338.813

SMILES

COc1cccc(NC(=S)NC(=O)c2c(Cl)c(C)nn2C)c1

Structure