Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM55615

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

75080±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM55615

n/a

Name

BDBM55615

Synonyms:

(Quinolin-8-yloxy)-acetic acid [1-(1-isopropyl-1H-indol-3-yl)-meth-(E)-ylidene]-hydrazide | MLS000588614 | N-[(1-isopropylindol-3-yl)methyleneamino]-2-(8-quinolyloxy)acetamide | N-[(1-propan-2-yl-3-indolyl)methylideneamino]-2-(8-quinolinyloxy)acetamide | N-[(1-propan-2-ylindol-3-yl)methylideneamino]-2-quinolin-8-yloxy-ethanamide | N-[(1-propan-2-ylindol-3-yl)methylideneamino]-2-quinolin-8-yloxyacetamide | SMR000219990 | cid_1991110

Type

Small organic molecule

Emp. Form.

C23H22N4O2

Mol. Mass.

386.4464

SMILES

CC(C)n1cc(C=NNC(=O)COc2cccc3cccnc23)c2ccccc12

Structure