Ki Summary

Reaction Details

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Target

Heat shock factor protein 1

Ligand

BDBM72269

Substrate/Competitor

n/a

Meas. Tech.

Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)

EC50

>260000±n/a nM

Citation

PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Heat shock factor protein 1

Name:

Heat shock factor protein 1

Synonyms:

HSF1_MOUSE | Hsf1 | Hsf1 protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57208.68

Organism:

Mus musculus

Description:

P38532

Residue:

525

Sequence:

MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPY
SAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQE
PPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPAL
PTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTM
PDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTG
SSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS

BDBM72269

n/a

Name

BDBM72269

Synonyms:

MLS000417372 | N-(3-cyano-2-thienyl)-2-[4-(2-naphthylsulfonyl)piperazino]acetamide | N-(3-cyano-2-thiophenyl)-2-[4-(2-naphthalenylsulfonyl)-1-piperazinyl]acetamide | N-(3-cyanothiophen-2-yl)-2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)acetamide | N-(3-cyanothiophen-2-yl)-2-(4-naphthalen-2-ylsulfonylpiperazin-1-yl)ethanamide | SMR000242545 | cid_2483113

Type

Small organic molecule

Emp. Form.

C21H20N4O3S2

Mol. Mass.

440.538

SMILES

O=C(CN1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1)Nc1sccc1C#N

Structure