| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
|---|
| Ligand | BDBM74989 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
|---|
| EC50 | >500000±n/a nM |
|---|
| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Importin subunit alpha-1 |
|---|
| Name: | Importin subunit alpha-1 |
|---|
| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57852.15 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_119609447 |
|---|
| Residue: | 529 |
|---|
| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
|
|
|
|---|
| BDBM74989 |
|---|
| n/a |
|---|
| Name | BDBM74989 |
|---|
| Synonyms: | 2-(4-keto-5,6-dimethyl-thieno[2,3-d]pyrimidin-3-yl)-N-[4-keto-4-(4-piperonylpiperazino)butyl]acetamide | MLS000729484 | N-[4-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-4-oxobutyl]-2-(5,6-dimethyl-4-oxo-3-thieno[2,3-d]pyrimidinyl)acetamide | N-[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-oxidanylidene-butyl]-2-(5,6-dimethyl-4-oxidanylidene-thieno[2,3-d]pyrimidin-3-yl)ethanamide | N-[4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-oxobutyl]-2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3-yl)acetamide | N-{4-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-4-oxobutyl}-2-(5,6-dimethyl-4-oxothieno[2,3-d]pyrimidin-3(4H)-yl)acetamide | SMR000307762 | cid_16193075 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31N5O5S |
|---|
| Mol. Mass. | 525.62 |
|---|
| SMILES | Cc1sc2ncn(CC(=O)NCCCC(=O)N3CCN(Cc4ccc5OCOc5c4)CC3)c(=O)c2c1C |
|---|
| Structure | 
|
|---|
Search and Browse
