| Reaction Details |
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 | Report a problem with these data |
| Target | Importin subunit alpha-1 |
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| Ligand | BDBM74993 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. |
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| EC50 | >500000±n/a nM |
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| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Importin subunit alpha-1 |
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| Name: | Importin subunit alpha-1 |
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| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57852.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_119609447 |
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| Residue: | 529 |
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| Sequence: | MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDA
TSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISE
QAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNK
NPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVK
LLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMS
NITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCG
IIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHE
NESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
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|
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| BDBM74993 |
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| n/a |
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| Name | BDBM74993 |
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| Synonyms: | MLS000728709 | N-[4-(2-thenoylamino)furazan-3-yl]thiophene-2-carboxamide | N-[4-(thiophen-2-ylcarbonylamino)-1,2,5-oxadiazol-3-yl]thiophene-2-carboxamide | N-[4-(thiophene-2-carbonylamino)-1,2,5-oxadiazol-3-yl]thiophene-2-carboxamide | N-[4-[[oxo(thiophen-2-yl)methyl]amino]-1,2,5-oxadiazol-3-yl]-2-thiophenecarboxamide | N-{4-[(thien-2-ylcarbonyl)amino]-1,2,5-oxadiazol-3-yl}thiophene-2-carboxamide | SMR000306988 | cid_573993 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H8N4O3S2 |
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| Mol. Mass. | 320.347 |
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| SMILES | O=C(Nc1nonc1NC(=O)c1cccs1)c1cccs1 |
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| Structure | 
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