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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Importin subunit alpha-1 | ||
| Ligand | BDBM75009 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. | ||
| EC50 | >500000±n/a nM | ||
| Citation |  PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay(2010)[AID] | ||
| More Info.: | Get all data from this article, Solution Info, Assay Method | ||
| Importin subunit alpha-1 | |||
| Name: | Importin subunit alpha-1 | ||
| Synonyms: | IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b | ||
| Type: | Enzyme Catalytic Domain | ||
| Mol. Mass.: | 57852.15 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | gi_119609447 | ||
| Residue: | 529 | ||
| Sequence: |
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| BDBM75009 | |||
| n/a | |||
| Name | BDBM75009 | ||
| Synonyms: | 4-[2,4-diketo-3-(o-tolyl)-1H-pyrimidin-6-yl]piperazine-1-carboxylic acid ethyl ester | 4-[3-(2-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]-1-piperazinecarboxylic acid ethyl ester | MLS000419323 | SMR000320085 | cid_16194587 | ethyl 4-[3-(2-methylphenyl)-2,4-bis(oxidanylidene)-1H-pyrimidin-6-yl]piperazine-1-carboxylate | ethyl 4-[3-(2-methylphenyl)-2,4-dioxo-1H-pyrimidin-6-yl]piperazine-1-carboxylate | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H22N4O4 | ||
| Mol. Mass. | 358.3917 | ||
| SMILES | CCOC(=O)N1CCN(CC1)c1cc(=O)n(-c2ccccc2C)c(=O)[nH]1 |(8.41,8.47,;7.08,7.7,;7.08,6.16,;5.75,5.39,;4.41,6.16,;5.75,3.85,;7.08,3.08,;7.08,1.54,;5.75,.77,;4.41,1.54,;4.41,3.08,;5.75,-.77,;7.08,-1.54,;7.08,-3.08,;8.41,-3.85,;5.75,-3.85,;5.75,-5.39,;7.08,-6.16,;7.08,-7.7,;5.75,-8.47,;4.41,-7.7,;4.41,-6.16,;3.08,-5.39,;4.41,-3.08,;3.08,-3.85,;4.41,-1.54,)| | ||
| Structure | 
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